Modelling the Effects of Antiretroviral Therapy on Kidney Diseases Among HIV Infected Individuals in Tanzania
DOI:
https://doi.org/10.4314/tjs.v50i5.13Keywords:
Kidney diseases, human immunodeficiency virus, highly active antiretroviral therapy, sensitivity analysis, HIV-infected individualsAbstract
This study examined the role of highly active antiretroviral therapy (HAART) in the dynamics of kidney diseases among HIV-infected individuals. A deterministic model was formulated for the dynamics of kidney disease in HIV-infected people with HAART as treatment in the model. Numerical simulations showed that though HAART reduces HIV progression to the AIDS stage, there is an increase in HIV-related kidney diseases. Also, the result obtained in this study showed that reducing the effective contact rate of HIV and improving the effectiveness of HAART by 99% in preventing the progression from HIV without symptoms group to HIV-related kidney diseases can decrease the prevalence of HIV-related kidney diseases. Therefore, based on the findings obtained to reduce the population of HIV-related kidney diseases in the general population Pharmacists should focus on improving HAART which will reduce the progression of kidney diseases from HIV.