Modelling the Effects of Antiretroviral Therapy on Kidney Diseases Among HIV Infected Individuals in Tanzania

Authors

  • Janeth Pancras Mchwampaka Eastern Africa Statistical Training Center, P.O. Box 35103 Dar es Salaam, Tanzania
  • Eunice Mureithi Department of Mathematics, University of Dar es Salaam, P.O. Box 35062, Dar es Salaam, Tanzania
  • Nyimvua Shaban Mbare Department of Mathematics, University of Dar es Salaam, P.O. Box 35062, Dar es Salaam, Tanzania

DOI:

https://doi.org/10.4314/tjs.v50i5.13

Keywords:

Kidney diseases, human immunodeficiency virus, highly active antiretroviral therapy, sensitivity analysis, HIV-infected individuals

Abstract

This study examined the role of highly active antiretroviral therapy (HAART) in the dynamics of kidney diseases among HIV-infected individuals. A deterministic model was formulated for the dynamics of kidney disease in HIV-infected people with HAART as treatment in the model. Numerical simulations showed that though HAART reduces HIV progression to the AIDS stage, there is an increase in HIV-related kidney diseases. Also, the result obtained in this study showed that reducing the effective contact rate of HIV and improving the effectiveness of HAART by 99% in preventing the progression from HIV without symptoms group to HIV-related kidney diseases can decrease the prevalence of HIV-related kidney diseases. Therefore, based on the findings obtained to reduce the population of HIV-related kidney diseases in the general population Pharmacists should focus on improving HAART which will reduce the progression of kidney diseases from HIV.

 

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Published

31-12-2024

How to Cite

Mchwampaka, J. P. ., Mureithi, E. ., & Mbare, N. S. . (2024). Modelling the Effects of Antiretroviral Therapy on Kidney Diseases Among HIV Infected Individuals in Tanzania. Tanzania Journal of Science, 50(5), 1060–1076. https://doi.org/10.4314/tjs.v50i5.13

Issue

Section

Mathematics and Computational Sciences