Incorporation Trends of (I-C14) Acetate in Pregnancy Lipids of Various Organs

Abstract

Comparative evaluation of (I-C¹⁴) acetate incorporation was studied in ovary, adrenal, blood plasma and placenta in guinea pigs in mid pregnancy. The respective level of incorporation within the sample for total lipids did not differ in pregnancy and non-pregnant states. Placental lipids in general, and phospholipids in particular were highly incorporated in contrast to other organs/tissues. Amongst non-pregnancy total lipids, the blood plasma showed an elevated incorporation over ovarian and adrenal lipids. The ovary in pregnancy revealed depressed incorporation in general, except for esterified cholesterol which contained higher incorporation.  Phosphatidyl choline in adrenal, and phosphatidyl ethanolamine in blood plasma appeared to be active fractions involved in respective phospholipid metabolism during pregnancy. Similar incorporation pattern in blood plasma and placenta with correspondingly increased activity in phosphatidyl ethanolamine, and depressed activity in phosphatidyl choline suggested that plasma tend to supplement the placental phosphatidyl ethanolamine source.