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TY  - JOUR
AU  - Mauti,  Godfrey O. 
PY  - 2022/12/30
Y2  - 2025/07/31
TI  - Antibacterial Potency of Allium sativum, Psidium guajava, Zingiber officinale Roots against the Food Poisoning Strains (Escherichia coli 0157:H7 and Staphylococcus aureus)
JF  - Tanzania Journal of Science
JA  - Tanz. J. Sci.
VL  - 48
IS  - 4
SE  - Articles
DO  - 10.4314/tjs.v48i4.11
UR  - https://tjs.udsm.ac.tz/index.php/tjs/article/view/1504
SP  - 843-850
AB  - &lt;p&gt;Escherichia &lt;em&gt;coli&lt;/em&gt; 0157:H7 and Staphylococcus &lt;em&gt;aureus&lt;/em&gt; are notorious food poisoning bacteria of great effect on human health. This study determined the phytochemical constituents of ethanolic, vacuum liquid chromatography (VLC) filtrates of Allium sativum (garlic), Psidium guajava (guava), &lt;em&gt;Zingiber&lt;/em&gt; &lt;em&gt;officinale&lt;/em&gt; (ginger) and their antibacterial activities on E. &lt;em&gt;coli&lt;/em&gt; 0157:H7 and S. &lt;em&gt;aureus&lt;/em&gt;. In a laboratory-based controlled experiment, the antibacterial and inhibitory activities of the VLC filtrates in doses of 0.01, 0.02, 0.04, and 0.08g/mL were investigated on E. &lt;em&gt;coli&lt;/em&gt; 0157:H7 and S. &lt;em&gt;aureus&lt;/em&gt; using the agar well diffusion method and compared with a standard antibiotic. The indices of the zone of inhibition on the agar plates were subjected to analysis of variance (&lt;em&gt;p&lt;/em&gt; = 0.01). Phytochemical analysis revealed a high concentration of glycosides, steroids, tannins, terpenoids, and the absence of flavonoids in A. sativum. P. guajava root contained a high concentration of glycosides, steroids, tannins, and terpenoids. &lt;em&gt;Z. officinale&lt;/em&gt; possessed a high concentration of alkaloids, glycosides, flavonoids, steroids, and terpenoids. Statistically, 0.02 g/mL of &lt;em&gt;Z.&lt;/em&gt; &lt;em&gt;officinale&lt;/em&gt; (12.0 mm) showed a significant result to 0.04g/mL of A. sativum (14mm) at p = 0.0049 and a higher inhibition index to 0.08g/mL of P. guajava. Inhibition by 0.02g/mL of P. guajava (8.8mm) was advanced than 0.04g/mL of A. sativum (6.3 mm) on S. aureus. Recommendable inhibition of 29.3 mm and 24.0 mm on &lt;em&gt;E. coli&lt;/em&gt; 0157:H7 and S. aureus, respectively, were expressed by 0.08 g/mL&lt;em&gt; Z. officinale&lt;/em&gt;, which was significant to the standard 0.04 g/mL of Neomycin (Positive control) at &lt;em&gt;p&lt;/em&gt; = 0.0067. This study indicated a reliable antibacterial activity by Z. officinale than A. sativum and P. guajava, which might have been due to the high concentration of alkaloids and flavonoids. Nevertheless, A. sativum, P. guajava, and &lt;em&gt;Z. officinale&lt;/em&gt; are normally used as fruit and food additives in the human diet, thus can be combined to prevent food poisoning by &lt;em&gt;E. coli&lt;/em&gt; 0157:H7 and S. aureus and their exotoxins.&lt;/p&gt;
ER  -