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@article{Ejidike_Bamigboye_Fadare_Adetunji_Obaleye_2022, title={Antimalarial and Antimicrobial Activities of some Heteroleptic Metal(II) Complexes of Sulfadiazine–Vitamin C: Synthesis and Spectroscopic Studies}, volume={48}, url={https://tjs.udsm.ac.tz/index.php/tjs/article/view/1515}, DOI={10.4314/tjs.v48i4.22}, abstractNote={<p>Some new Ni(II), Zn(II), Co(II), Cu(II), and Cd(II) of mixed Sulphadiazine and Vitamin C complexes have been synthesized and characterized by different spectroscopic techniques such as FT-IR, elemental analysis, molar conductivity, and magnetic measurements. Both ligands used for this research work act as bidentate ligands towards the central metal ions coordinating through the nitrogen atoms of >C=N–, NH<sub>2</sub> groups of Sulphadiazine and oxygen atoms of OH, CO groups of Vitamin C. Tetrahedral and square-planar geometries have been proposed for the complexes. The complexes are stable under atmospheric conditions. The ligands and their complexes were screened for antimicrobial activities against some isolated organisms: <em>Klebsiella pneumoniae, Bacillus subtilis, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa </em>and<em> Enterococcus faecalis </em>to evaluate their microbial inhibiting potential. The derived complexes were found to exhibit an increased inhibitory action against the organisms when compared to the free ligands. The percentage reduction in <em>parasitaemia</em> for the compounds was also evaluated against<em> Plasmodium berghei</em>. In this realm, [Cd(Su)(Vit)]Cl<sub>2 </sub>showed the highest activity (89%) as compared to other compounds: Sulphadiazine, Ni(II), Zn(II), Co(II), and Cu(II) complexes are 70, 50, 81, 76, and 77%, respectively, Vitamin C showed no activity.</p>}, number={4}, journal={Tanzania Journal of Science}, author={Ejidike, Ikechukwu P. and Bamigboye, Mercy O. and Fadare, Dorcas A. and Adetunji, Juliana B. and Obaleye, Joshua A.}, year={2022}, month={Dec.}, pages={973–984} }